{"id":12,"date":"2022-08-02T21:09:32","date_gmt":"2022-08-02T21:09:32","guid":{"rendered":"https:\/\/geographicatrophy.info\/?page_id=12"},"modified":"2026-03-26T12:46:12","modified_gmt":"2026-03-26T12:46:12","slug":"iperattivazione-del-complemento","status":"publish","type":"page","link":"https:\/\/staging.geographicatrophy.info\/it\/iperattivazione-del-complemento\/","title":{"rendered":"Iperattivazione del complemento"},"content":{"rendered":"<div class=\"default-block container-fluid\">\n\n\n\n<div class=\"row titleWithImage left\">\n\t<div class=\"col-12\">\n\t\t<div class=\"container\">\n\t\t\t<div class=\"row\">\n\t\t\t\t<div class=\"col-12\">\n                    \t\t\t\t\t\t\t\t\t\t\t<h1 class=\"titleWithImage__title titleWithImage__title--left\">Iperattivazione del complemento<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h2 class=\"titleWithImage__subtitle titleWithImage__subtitle--left\">Il sistema del complemento svolge un ruolo fondamentale nella risposta immunitaria, <br \/>\r\nma l\u2019iperattivazione pu\u00f2 essere dannosa ed \u00e8 associata a diverse malattie gravi, tra cui l\u2019atrofia geografica.<sup>1<\/sup><\/h2>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t\t<img decoding=\"async\" class=\"titleWithImage__image\" loading=\"lazy\" alt=\"Geographic Atrophy\" src=\"https:\/\/staging.geographicatrophy.info\/it\/wp-content\/uploads\/sites\/6\/2022\/08\/image_hero_3.png\" \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t   \t\t\t\tstyle=\"object-position: center center\" >\n\t\t\t<div class=\"titleWithImage__over\"><\/div>\n\t\t\n\t<\/div>\n<\/div>\n\n\t<\/div>\n\n<div class=\"default-block container\">\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<div class=\"default-block container\">\n<h2 class=\"wp-block-heading has-text-align-center d-block d-lg-none has-orange-color has-text-color\">Gli effetti dannosi dell\u2019iperattivazione del complemento nell\u2019atrofia geografica<\/h2>\n<\/div>\n\n<div class=\"default-block container\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"default-block container\">\n<figure class=\"wp-block-video\"><video height=\"2160\" style=\"aspect-ratio: 3840 \/ 2160;\" width=\"3840\" controls poster=\"https:\/\/geographicatrophy.info\/it\/wp-content\/uploads\/sites\/6\/2023\/01\/ga-eu_IT_4_complement-overactivation_images_MoA-videocoverpng-scaled.webp\" src=\"https:\/\/geographicatrophy.info\/it\/wp-content\/uploads\/sites\/6\/2023\/01\/220913_dryAMD_MoA_Video_IT.mp4\"><\/video><\/figure>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\"><div class=\"default-block container\">\n<h2 class=\"wp-block-heading d-none d-lg-block has-orange-color has-text-color\">Gli effetti dannosi dell\u2019iperattivazione del complemento nell\u2019atrofia geografica<\/h2>\n<\/div>\n\n<div class=\"default-block container\">\n<p><strong>L\u2019iperattivazione del sistema del complemento \u00e8 stata implicata nella perdita di cellule retiniche e nell\u2019AG, in cui le lesioni causano la morte dell\u2019epitelio pigmentato retinico (EPR) e delle cellule fotorecettrici nella macula.<sup>2<\/sup><\/strong><\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<div class=\"default-block container\">\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<div class=\"default-block container-fluid\">\n<div class=\"wp-block-group alignfull has-bg-dark-background-color has-background\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"default-block container\">\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<div class=\"default-block container\">\n<h2 class=\"wp-block-heading has-text-align-center has-orange-color has-text-color\">Cos\u2019\u00e8 il sistema del complemento?<\/h2>\n<\/div>\n\n<div class=\"default-block container\">\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<div class=\"default-block container\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/geographicatrophy.info\/wp-content\/uploads\/2022\/08\/icon_circle8.svg\" alt=\"geographicatrophy.info - icona essere umano\" class=\"wp-image-65\"\/><\/figure>\n<\/div>\n\n<div class=\"default-block container\">\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<div class=\"default-block container\">\n<p>Il sistema del complemento \u00e8 parte integrante del sistema di difesa immunitaria. Nelle persone sane il complemento orchestra la distruzione e la pulizia dei patogeni o delle cellule dell\u2019organismo che devono essere rimosse. Ha inoltre capacit\u00e0 proinfiammatorie.<sup>3<\/sup><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/geographicatrophy.info\/wp-content\/uploads\/2022\/08\/icon_circle9.svg\" alt=\"geographicatrophy.info - icona scudo\" class=\"wp-image-66\"\/><\/figure>\n<\/div>\n\n<div class=\"default-block container\">\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<div class=\"default-block container\">\n<p>L\u2019attivazione del complemento \u00e8 regolata per evitarne l\u2019iperattivazione e proteggere l\u2019organismo da attacchi immunitari inappropriati. Quando la regolazione \u00e8 compromessa, l\u2019iperattivazione della cascata del complemento pu\u00f2 causare infiammazione e distruzione inappropriata di cellule.<sup>3<\/sup><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"148\" height=\"150\" src=\"https:\/\/geographicatrophy.info\/wp-content\/uploads\/2022\/08\/icon_circle10.svg\" alt=\"geographicatrophy.info - icona tre pathway\" class=\"wp-image-67\"\/><\/figure>\n<\/div>\n\n<div class=\"default-block container\">\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<div class=\"default-block container\">\n<p>Tre pathway convergono con il clivaggio del fattore C3 del complemento, che induce infiammazione e marca le cellule per la fagocitosi (distruzione da parte di speciali globuli bianchi). La cascata del complemento continua con il clivaggio del fattore C5 del complemento, che innesca la morte cellulare tramite fagocitosi, infiammazione e, in ultima analisi, attivazione del complesso di attacco alla membrana (Membrane Attack Complex, MAC), che causa danni e morte cellulare.<sup>3<\/sup><\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<div class=\"default-block container\">\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n<div class=\"default-block container\">\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<div class=\"default-block container\">\n<h2 class=\"wp-block-heading has-text-align-left has-orange-color has-text-color\">Conseguenze dell\u2019iperattivazione del complemento nell\u2019AG<sup>2,4,5<\/sup><\/h2>\n<\/div>\n\n<div class=\"default-block container\">\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<div class=\"default-block container\">\n<div class=\"default-block container\" style=\"padding-left: 0 !important;\"><p class=\"has-text-align-left\">Il grafico e i video che seguono riassumono le conseguenze dell\u2019iperattivazione del complemento nell\u2019atrofia geografica.<\/p><\/div>\n<\/div>\n\n<div class=\"default-block container\">\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"697\" src=\"https:\/\/geographicatrophy.info\/it\/wp-content\/uploads\/sites\/6\/2022\/12\/cascade_IT-1024x697.webp\" alt=\"\" class=\"wp-image-2257\" srcset=\"https:\/\/staging.geographicatrophy.info\/it\/wp-content\/uploads\/sites\/6\/2022\/12\/cascade_IT-1024x697.webp 1024w, https:\/\/staging.geographicatrophy.info\/it\/wp-content\/uploads\/sites\/6\/2022\/12\/cascade_IT-300x204.webp 300w, https:\/\/staging.geographicatrophy.info\/it\/wp-content\/uploads\/sites\/6\/2022\/12\/cascade_IT-768x523.webp 768w, https:\/\/staging.geographicatrophy.info\/it\/wp-content\/uploads\/sites\/6\/2022\/12\/cascade_IT-1536x1046.webp 1536w, https:\/\/staging.geographicatrophy.info\/it\/wp-content\/uploads\/sites\/6\/2022\/12\/cascade_IT-2048x1395.webp 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n<div class=\"default-block container\">\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<div class=\"default-block container\">\n<h2 class=\"wp-block-heading has-text-align-center has-orange-color has-text-color\">La cascata del complemento e il suo potenziale terapeutico nell\u2019atrofia geografica<\/h2>\n<\/div>\n\n<div class=\"default-block container\">\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n\n<p class=\"has-text-align-center\">Tutte e tre i pathway del complemento convergono su C3 e ci\u00f2 determina molteplici effetti dannosi a valle, cosa che lo rende un bersaglio terapeutico interessante<sup>6<\/sup>. Questo potenziale \u00e8 gi\u00e0 stato dimostrato in studi in cui \u00e8 stato osservato un beneficio clinico in pazienti affetti da atrofia geografica.<sup>7<\/sup><\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong>Pertanto, agire sulla cascata del complemento, in particolare a livello di C3, potrebbe offrire un\u2019opzione di trattamento per i soggetti affetti da atrofia geografica.<sup>7<\/sup><\/strong><\/p>\n\n\n<div class=\"default-block container\">\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<div class=\"default-block container\">\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<div class=\"default-block container-fluid\">\n<div class=\"wp-block-group alignfull\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"default-block container\">\n<h2 class=\"wp-block-heading has-text-align-center d-block  has-orange-color has-text-color\">Ulteriori informazioni sul sistema del complemento<\/h2>\n<\/div>\n\n\n<p class=\"has-text-align-center d-block \"><strong>La seguente serie di video fornisce una panoramica pi\u00f9 completa del sistema del complemento e del suo ruolo nella degenerazione maculare legata all\u2019et\u00e0.<\/strong><\/p>\n\n\n<div class=\"default-block container\">\n<div class=\"wp-block-columns video-player is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\"><div class=\"default-block container\">\n<div class=\"specialButton on_right\"><a href=\"#\" class=\"specialButton__button\" target=\"\">Il ruolo del sistema del complemento<\/a><\/div>\n<\/div>\n\n<div class=\"default-block container\">\n<div class=\"specialButton on_right\"><a href=\"#\" class=\"specialButton__button\" target=\"\">Il ruolo dell\u2019attivazione del complemento nell\u2019atrofia geografica<\/a><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"default-block container\">\n<figure class=\"wp-block-video\"><video height=\"720\" style=\"aspect-ratio: 1280 \/ 720;\" width=\"1280\" controls poster=\"https:\/\/geographicatrophy.info\/it\/wp-content\/uploads\/sites\/6\/2023\/01\/ga-eu_IT_4_complement-overactivation_images_C3-1-videocover.png\" src=\"https:\/\/geographicatrophy.info\/wp-content\/uploads\/2022\/08\/dryAMD_complement_system_part_1_2.mp4\"><\/video><\/figure>\n<\/div>\n\n<div class=\"default-block container\">\n<figure class=\"wp-block-video\"><video height=\"2160\" style=\"aspect-ratio: 3840 \/ 2160;\" width=\"3840\" controls poster=\"https:\/\/geographicatrophy.info\/it\/wp-content\/uploads\/sites\/6\/2023\/01\/ga-eu_IT_4_complement-overactivation_images_C3-2-videocover.png\" src=\"https:\/\/geographicatrophy.info\/it\/wp-content\/uploads\/sites\/6\/2023\/01\/dryAMD-eu_IT_6-science_video_C3-2-video.mp4\"><\/video><\/figure>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<div class=\"default-block container\">\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n<div id=\"sign-up-confirmation\" class=\"form-sign-up\" style=\"--background: url('https:\/\/staging.geographicatrophy.info\/it\/wp-content\/uploads\/sites\/6\/2022\/09\/iris_2@2x.png')\">\n    <div class=\"container\">\n        <div class=\"row\">\n            <div class=\"form-sign-up__col col-12 col-lg-6\">\n                <div class=\"form-sign-up__col-wrapper\" id=\"form-sign__entry\">\n                    <div class=\"form-sign-up__header\">\n                        <h2 class=\"form-sign-up__header-title\">\n                            <span class=\"form-sign-up__header-title--white\">Unisciti a noi<\/span>\n                            <span class=\"form-sign-up__header-title--yellow\">nel nostro viaggio nell\u2019atrofia geografica<\/span>\n                        <\/h2>\n                        <p><strong>Sii il primo\u00a0<\/strong>a ricevere le ultime notizie sull\u2019atrofia geografica<\/p>\n                    <\/div>\n                                        <div class=\"form-sign-up__form\">\n                        <form id=\"signup_form__form\" action=\"https:\/\/staging.geographicatrophy.info\/it\/wp-content\/themes\/apellis-ga-hub\/form-sign-up-handler.php\" method=\"POST\">\n                        <input name=\"language\" id=\"language\" type=\"hidden\" value=\"IT\">\n                        <input type=\"hidden\" name=\"g-recaptcha-response\" id=\"recaptcha-token\">\n                        <input name=\"form-sign-up-name-field\" id=\"form-sign-up-name-field\" type=\"text\" value=\"\">\n                        <input name=\"country\" id=\"country\" type=\"hidden\" value=\"Italy\">\n                        <input name=\"pageUrl\" id=\"pageUrl\" type=\"hidden\" value=\"https:\/\/staging.geographicatrophy.info\/it\/wp-json\/wp\/v2\/pages\/12\">\n                        <input name=\"returnUrl\" id=\"returnUrl\" type=\"hidden\" value=\"https:\/\/staging.geographicatrophy.info\/it\/wp-json\/wp\/v2\/pages\/12#sign-up-confirmation\">\n\n                            <div class=\"form-sign-up__form-wrapper\">\n                                <div>\n                                    <label class=\"form-sign-up__label\" for=\"fname\">Nome<sup>*<\/label>\n                                    <input required class=\"form-sign-up__input\" id=\"fname\" name=\"fname\" type=\"text\" value=\"\" required>\n                                <\/div>\n                                <div>\n                                    <label class=\"form-sign-up__label\" for=\"lname\">Cognome<sup>*<\/label>\n                                    <input required  class=\"form-sign-up__input\" id=\"lname\" name=\"lname\" type=\"text\" value=\"\" required>\n                                <\/div>\n                                <div>\n                                    <label class=\"form-sign-up__label\" for=\"email\">Indirizzo e-mail<sup>*<\/label>\n                                    <input required class=\"form-sign-up__input\" id=\"email\" name=\"email\" type=\"email\" value=\"\" required>\n                                <\/div>\n                                <div class=\"form-sign-up__select-container\">\n                                    <label id=\"form-sign-up-label-speciality\" class=\"form-sign-up__label\" for=\"speciality\">Specialit\u00e0<sup>*<\/label>\n                                    <div id=\"speciality-input-button\" class=\"form-sign-up__select-button\">\n                                        <p id=\"speciality-input-value\">Specialit\u00e0<\/p>\n                                        <img decoding=\"async\" id=\"speciality-input-arrow-icon\" class=\"form-sign-up__select-arrow-icon\" src=\"\/wp-content\/themes\/apellis-ga-hub\/assets\/img\/chevron.svg\" alt=\"Orange arrow icon\">\n                                    <\/div>\n                                    <p id=\"form-sign-up-speciality-error-message\" class=\"form-sign-up__error-message\">Please fill in this field<\/p>\n                                    <ul id=\"speciality-input-menu\" class=\"form-sign-up__select-menu\">\n                                        <li class=\"form-sign-up__select-menu-item\">Specialista della retina<\/li>\n                                        <li class=\"form-sign-up__select-menu-item\">Oftalmologo<\/li>\n                                        <li class=\"form-sign-up__select-menu-item\">Optometrista<\/li>\n                                        <li class=\"form-sign-up__select-menu-item\">Farmacista<\/li>\n                                        <li class=\"form-sign-up__select-menu-item\">Infermiere<\/li>\n                                        <li class=\"form-sign-up__select-menu-item\">Preferisco non dire<\/li>\n                                        <li class=\"form-sign-up__select-menu-item\"><\/li>\n                                        <li class=\"form-sign-up__select-menu-item\"><\/li>\n                                        <li class=\"form-sign-up__select-menu-item\"><\/li>\n                                        <li class=\"form-sign-up__select-menu-item\"><\/li>\n                                    <\/ul>\n                                    <input name=\"specialty\" id=\"specialty\" type=\"hidden\" value=\"Select Speciality\" \/>\n                                <\/div>\n                                <div>\n                                    <button class=\"form-sign-up__button button button__orange button__arrow-white\" type=\"submit\" name=\"submit\" id=\"submit-btn\" value=\"submit\">Iscriviti<\/button>\n                                <\/div>\n                            <\/div>\n                        <\/form>\n                    <\/div>\n                    <div class=\"form-sign-up__footer\">\n                        <p><b>Informativa sulla privacy:<\/b>\u00a0facendo clic su \u201cRegistrati\u201d accetto che Apellis possa contattarmi via e-mail e comprendo che le mie informazioni saranno soggette alla loro\u00a0<a class=\"nav-link local\" href=\"https:\/\/geographicatrophy.info\/it\/informativa-sulla-privacy\/\" target=\"_new\">informativa sulla privacy<\/a>.<\/p>\n                    <\/div>\n                <\/div>\n                <div class=\"form-sign-up__container-successful\" id=\"form-signup__success\">\n                    <div>\n                        <img decoding=\"async\" class=\"form-sign-up__successful-image\" src=\"\/wp-content\/uploads\/2023\/11\/Icon_submitted-successfully@2x.png\" alt=\"Thank You Message Icom\">\n                    <\/div>\n                    <div>\n                        <h2 class=\"form-sign-up__successful-message\"><strong>Grazie<\/strong> per aver inviato i tuoi dati. <\/h2>\n                        <h2 class=\"form-sign-up__successful-message\">Controlla le tue e-mail per verificare la tua iscrizione.<\/h2>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"default-block container-fluid\">\n<div class=\"wp-block-group alignfull has-bg-light-background-color has-background\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"default-block container\">\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n<div class=\"default-block container\">\n<p><strong>Bibliografia<\/strong><\/p>\n<\/div>\n\n<div class=\"default-block container\">\n<ol class=\"wp-block-list has-small-font-size\"><div class=\"default-block container\">\n<li>Liao, D.S, <em>et al.<\/em> (2020). Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration.\u00a0<em>Ophthalmology<\/em>, 127(2), pp.186\u2013195. doi:10.1016\/j.ophtha.2019.07.011..<\/li>\n<\/div>\n\n<div class=\"default-block container\">\n<li>Katschke, K.J. <em>et al.<\/em> (2018). Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy.\u00a0<em>Scientific Reports<\/em>, [online] 8(1), p.7348. doi:10.1038\/s41598-018-25557-8.<\/li>\n<\/div>\n\n<div class=\"default-block container\">\n<li>Murphy K, Weaver C. Innate immunity: the first lines of defense. In: <em>Janeway\u2019s Immunobiology<\/em>. 9a ed. Londra, Regno Unito: Garland Science; 2016.<\/li>\n<\/div>\n\n<div class=\"default-block container\">\n<li>Mastellos, D.C. <em>et al.<\/em> (2017). Complement C3-Targeted Therapy: Replacing Long-Held Assertions with Evidence-Based Discovery.\u00a0<em>Trends in Immunology<\/em>, [online] 38(6), pp.383\u2013394. doi:10.1016\/j.it.2017.03.003.<\/li>\n<\/div>\n\n<div class=\"default-block container\">\n<li>Ricklin, D. (2016). Complement component C3 &#8211; The \u2018Swiss Army Knife\u2019 of innate immunity and host defense.\u00a0<em>Immunological Reviews<\/em>, 274(1), pp.33\u201358. doi:10.1111\/imr.12500.<\/li>\n<\/div>\n\n<div class=\"default-block container\">\n<li>Sahu, A. (2001). Structure and biology of complement protein C3, a connecting link between innate and acquired immunity.\u00a0<em>Immunological Reviews<\/em>, 180(1), pp.35\u201348. doi:10.1034\/j.1600-065x.2001.1800103.x.<\/li>\n<\/div>\n\n<div class=\"default-block container\">\n<li>Kim, B.J. <em>et al. <\/em>(2020)  Mastellos DC, Li Y, Dunaief JL, Lambris JD. Targeting complement components C3 and C5 for the retina: Key concepts and lingering questions. <em>Prog Retin Eye Res. <\/em>100936 doi: 10.1016\/j.preteyeres.2020.100936.<\/li>\n<\/div><\/ol>\n<\/div>\n\n<div class=\"default-block container\">\n<p><\/p>\n<\/div>\n\n<div class=\"default-block container\">\n<p>EU-GA-2300007\u00a0\u00a0\u00a0\u00a0\u00a0April 2026<\/p>\n<\/div>\n\n<div class=\"default-block container\">\n<p><\/p>\n<\/div>\n\n<div class=\"default-block container\">\n<p><\/p>\n<\/div>\n\n<div class=\"default-block container\">\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Gli effetti dannosi dell\u2019iperattivazione del complemento nell\u2019atrofia geografica Gli effetti dannosi dell\u2019iperattivazione del complemento nell\u2019atrofia geografica L\u2019iperattivazione del sistema del complemento \u00e8 stata implicata nella perdita di cellule retiniche e nell\u2019AG, in cui le lesioni causano la morte dell\u2019epitelio pigmentato retinico (EPR) e delle cellule fotorecettrici nella macula.2 Cos\u2019\u00e8 il sistema del complemento? Il sistema [&hellip;]<\/p>\n","protected":false},"author":193,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"class_list":["post-12","page","type-page","status-publish","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/staging.geographicatrophy.info\/it\/wp-json\/wp\/v2\/pages\/12","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.geographicatrophy.info\/it\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/staging.geographicatrophy.info\/it\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/staging.geographicatrophy.info\/it\/wp-json\/wp\/v2\/users\/193"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.geographicatrophy.info\/it\/wp-json\/wp\/v2\/comments?post=12"}],"version-history":[{"count":0,"href":"https:\/\/staging.geographicatrophy.info\/it\/wp-json\/wp\/v2\/pages\/12\/revisions"}],"wp:attachment":[{"href":"https:\/\/staging.geographicatrophy.info\/it\/wp-json\/wp\/v2\/media?parent=12"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}